Month: August 2019

There May Be a Way to Prevent Liver Damage from Alcohol

first_imgThere May Be a Way to Prevent Liver Damage from Alcohol Mass General just published the results of a promising animal study. Print 000 4/25/2017, 11:35 a.m. Read all about the latest gym openings, healthy events, and fitness trends in our twice weekly Wellness newsletter. center_img By Jamie Ducharme· Sign up for Health & Wellness newsletters. Everything you need to stay healthy and fit.* Alcohol photo via istock.com/Jonathan Austin DanielsLiver disease is one of the most serious consequences of alcohol abuse, killing roughly 20,000 Americans in 2014 alone.Someday, Massachusetts General Hospital research may help reduce some of that damage—or, better yet, prevent it in the first place. According to a new paper, an enzyme called intestinal alkaline phosphatase (IAP) seems to prevent the development of fatty liver—the earliest stage of alcohol-induced liver disease—in mice. Someday, perhaps, the same could be true for humans.The Mass General group, which published its research in the journal Digestive Diseases and Sciences, focused on IAP because it has been shown to counteract the damaging effects of a molecule called lipopolysaccharide (LPS). Prior mouse studies from the lab of Mass General’s Richard Hodin found that IAP can prevent LPS-borne bacterial toxins from leaching into the bloodstream via the gastrointestinal tract, and help prevent metabolic syndrome—a disease encompassing symptoms such as obesity, metabolic issues, and fatty liver—by blocking LPS.LPS, as it happens, also plays a role in alcohol-induced liver disease. Could IAP help prevent that, too?To test the theory, the researchers manipulated mice to model the effects of both short-term binge drinking and chronic alcohol consumption. In both instances, taking IAP either before or at the same time as an alcohol dose reduced common signs of liver disease, including inflammation and fatty liver. IAP also seemed to prevent the activation of hepatic stellate cells, which contribute to alcoholic fatty liver.Taking IAP after alcohol, however, did not offer protective benefits.There’s no guarantee, of course, that IAP will work the same way in humans. Even if it does, it would take years to translate the raw findings into a marketable treatment. Doing so, however, could have a huge impact on public health.“Liver damage is one of the most devastating effects of excess alcohol consumption,” lead author Hodin says in a statement, “and so blocking this process could save millions of lives lost to alcohol-related liver diseases such as cirrhosis and liver cancer.”last_img read more

On the Market An 1850s Jewel in Somerville

first_img 990100 Photo via Better Homes and Gardens Real Estate18 Mount Vernon Street, SomervillePrice: $699,000Size: 1,530 square feetBedrooms: 3Baths: 2It’s sad, but it’s true: You’re lucky if you can score a condo for $699,000 in Somerville, nevermind an antique single-family. That’s part of what makes this Italianate Victorian for sale so special—it’s somewhat of an agreeable price for the neighborhood. That, and it happens to be less than a 10-minute walk from the T.Nestled on a side street near Sullivan Square station, the 1850 home stuns inside and out. A gracious entryway opens to a foyer where the home’s preservation work is put on display. Look left to see period pocket doors in the living room, then right to glimpse restored woodwork and built-ins. The kitchen, meanwhile, boasts more modern updates, like new appliances and a subway tile backsplash. Continue through the house to reach the fenced-in backyard, complete with a brick patio area and several raised garden beds.For information, contact Dara Singleton, Better Homes and Gardens Real Estate – The Shanahan Group, shanahanre.com.Photo via Better Homes and Gardens Real EstatePhoto via Better Homes and Gardens Real EstatePhoto via Better Homes and Gardens Real EstatePhoto via Better Homes and Gardens Real EstatePhoto via Better Homes and Gardens Real EstatePhoto via Better Homes and Gardens Real EstatePhoto via Better Homes and Gardens Real EstatePhoto via Better Homes and Gardens Real EstatePhoto via Better Homes and Gardens Real EstatePhoto via Better Homes and Gardens Real EstatePhoto via Better Homes and Gardens Real EstatePhoto via Better Homes and Gardens Real EstatePhoto via Better Homes and Gardens Real EstatePhoto via Better Homes and Gardens Real EstatePhoto via Better Homes and Gardens Real EstatePhoto via Better Homes and Gardens Real EstatePhoto via Better Homes and Gardens Real EstatePhoto via Better Homes and Gardens Real EstatePhoto via Better Homes and Gardens Real EstatePhoto via Better Homes and Gardens Real EstateThe Boston Home team has curated a list of the best home design and home remodeling professionals in Boston, including architects, builders, kitchen and bath experts, lighting designers, and more. Get the help you need with FindIt/Boston’s guide to home renovation pros. Sign up for our weekly home and property newsletter, featuring homes for sale, neighborhood happenings, and more. Sign up for Home & Property newsletters. Design, real estate, and pretty things for living.* Printcenter_img By Madeline Bilis· 1/29/2019, 2:16 p.m. For Sale/Rent On the Market: An 1850s Jewel in Somerville This Italianate Victorian is less than a 10-minute walk from Sullivan Square station.last_img read more

British Open 2019 Tiger Woods odds to win fourth Open Championship

first_imgThe 2019 British Open kicks off this week at Royal Portrush in Northern Ireland, and there’s one man who has won more Claret Jugs than anyone else in the field: Tiger Woods.A three-time British Open champion, Woods enters the fourth and final major of the year with 18/1 odds to win, which are the fifth-best odds entering the event. Only Rory McIlroy, Brooks Koepka, Dustin Johnson, and Jon Rahm have better odds to win this week.He hasn’t played since his T21 at the U.S. Open last month, and he hasn’t won the Claret Jug since 2006. But the 15-time major champion won the Masters this past April and finished T6 in last year’s tournament at Carnoustie. In between Augusta National and Pebble Beach, Woods failed to make the cut at the PGA Championship and finished T9 at the Memorial Tournament.Getty Imageslast_img read more