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Pepper painkiller hot topic among doctors

first_img AD Quality Auto 360p 720p 1080p Top articles1/5READ MOREGame Center: Chargers at Kansas City Chiefs, Sunday, 10 a.m.How could something searing possibly soothe? Bite a hot pepper, and after the burn your tongue goes numb. The hope is that bathing surgically exposed nerves in a high-enough dose will numb them for weeks, so that patients suffer less pain and require fewer narcotic painkillers as they heal. “We wanted to exploit this numbness” is how Dr. Eske Aasvang, a pain specialist in Denmark who is testing the substance, puts it. Chili peppers have been part of folk remedy for centuries, and heat-inducing capsaicin creams are a drugstore staple for aching muscles. But today the spice is hot because of research showing that capsaicin targets key pain-sensing cells in a unique way. California-based Anesiva Inc.’s operating-room experiments aren’t the only attempt to harness that burn for more focused pain relief. WASHINGTON: Doctors are experimenting with a chemical that makes peppers hot as a numbing agent during painful surgeries. Devil’s Revenge. Spontaneous Combustion. Hot sauces have names like that for a reason. Now scientists are testing whether the stuff that makes the sauces so savage can tame the pain of surgery. Doctors are dripping the chemical that gives chili peppers their fire directly into open wounds during knee replacement and a few other highly painful operations. Don’t try this at home: These experiments use an ultra-purified version of capsaicin to avoid infection – and the volunteers are under anesthesia so they don’t scream at the initial burn. Harvard University researchers are mixing capsaicin with another anesthetic in hopes of developing epidurals that wouldn’t confine women to bed during childbirth, or dental injections that don’t numb the whole mouth. And at the National Institutes of Health, scientists hope early next year to begin testing in advanced cancer patients a capsaicin cousin that is 1,000 times more potent, to see if it can zap their intractable pain. Nerve cells that sense a type of long-term throbbing pain bear a receptor, or gate, called TRPV1. Capsaicin binds to that receptor and opens it to enter only those pain fibers – and not other nerves responsible for other kinds of pain or other functions such as movement. These so-called C neurons also sense heat; thus capsaicin’s burn. But when TRPV1 opens, it lets extra calcium inside the cells until the nerves become overloaded and shut down. That’s the numbness. “It just required a new outlook about … stimulation of this receptor” to turn those cellular discoveries into a therapy hunt, says the NIH’s Dr. Michael Iadarola. Enter Anesiva’s specially purified capsaicin, called Adlea. Experiments are under way involving several hundred patients undergoing various surgeries, including knee and hip replacements. Surgeons drip either Adlea or a dummy solution into the cut muscle and tissue and wait five minutes for it to soak in before stitching up the wound. Among early results: In a test of 41 men undergoing open hernia repair, capsaicin recipients reported significantly less pain in the first three days after surgery, Aasvang reported this month at a meeting of the American Society of Anesthesiologists. Ongoing studies are testing larger doses in more patients to see whether the effect is real.160Want local news?Sign up for the Localist and stay informed Something went wrong. Please try again.subscribeCongratulations! You’re all set!last_img read more

COUNCILLOR PLEADS TO COUNCIL NOT TO ALLOW RECYCLE BINS TO OVERFLOW

first_imgDonegal County Councillor Micheal Mac Giolla Easbuig is pleading with the council not to allow recycling banks to overflow at Christmas.The Independent councillor said the banks are often allowed to build up and look unsightly over the festive season.“I have been in contact with Donegal county council in relation to our recycling banks and how at Christmas and New Year they are not emptied often enough. That leads to the surrounding areas at some of the centres ending up very untidy.“I have been told that there has been an extra lorry put in place this year to deal with the problem and that the staff of Donegal county council will be at hand over the holiday period to maintain the centres as well. “We as a community also have a responsibility to make sure that we don’t throw our empty boxes or other rubbish at the centre points. Also we must acknowledge the great work that is being done by volunteers and workers throughout our community to keep the centres clean and tidy all year long.”COUNCILLOR PLEADS TO COUNCIL NOT TO ALLOW RECYCLE BINS TO OVERFLOW was last modified: December 22nd, 2015 by StephenShare this:Click to share on Facebook (Opens in new window)Click to share on Twitter (Opens in new window)Click to share on LinkedIn (Opens in new window)Click to share on Reddit (Opens in new window)Click to share on Pocket (Opens in new window)Click to share on Telegram (Opens in new window)Click to share on WhatsApp (Opens in new window)Click to share on Skype (Opens in new window)Click to print (Opens in new window) Tags:councildonegalrecycling bankslast_img read more

Gackle: the Erik Karlsson experiment hinges on Sharks’ playoff success

first_imgCLICK HERE if you are having a problem viewing the photos on a mobile deviceSAN JOSE — The great Erik Karlsson experiment is hanging on a muscle tendon.When Doug Wilson pulled off the trade of the decade by acquiring Karlsson on the eve of training camp, the hockey world appeared to be the Sharks oyster. Karlsson’s addition to a blue line that already featured Brent Burns and Marc-Edouard Vlasic made the Sharks instant Stanley Cup front runners.They delivered on that promise for 19 games, …last_img

Makana Football founders honoured

first_imgA scene from More Than Just a Game, a film that told the story of ex-political prisoners Mark Shinners, Anthony Suze, Lizo Sitoto, Sedick Isaacs and Marcus Solomon. (Image: More Than Just a Game) Fifa honoured Makana FA founders in 2007 by making the association its honorary member. (Image: Fifa) Minister Tokyo Sexwale kicking a ball in Ekangala recently, reminding himself of his playing days in Robben Island. (Image: Bongani Nkosi) MEDIA CONTACTS • Chris Johnston Media Officer De Montfort University +44 116 207 8010 RELATED ARTICLES • Top honour for Bafana captain • National Orders recipients named • Chancellor House to honour icons • South Africa: a top film locationBongani NkosiPlaying football was a form of escapism for Robben Island’s political prisoners, bringing them temporary relief from their incarceration by the apartheid government.More than 300 men used to gather at the grounds on the island to play their favourite sport in a league administrated by Makana Football Association, which was formed and run by the prisoners.Now the UK’s De Montfort University is to honour four struggle heroes who campaigned to bring the Beautiful Game to the island in the mid-1960s, then a hard labour prison.Mark Shinners, Sedick Isaacs, Lizo Sitoto and Marcus Solomon, icons from both the Pan Africanist Congress of Azania and the African National Congress, will be honoured with the Companionship of De Montfort University at a graduation ceremony in Leicester on 22 July 2011.The university will honour the four in recognition of the role they played in “giving new hope to the prisoners of the notorious Robben Island, through playing the popular game”, it said.Besides a gala dinner at the university, the group will also be treated to tours of the world-famous Wembley Stadium and Houses of Parliament in London. The South African High Commission will also honour them at South Africa House in Trafalgar Square. It took the men three years to convince apartheid officials to allow prisoners, some then only in their 20s, to play football on the island. At first the men were punished for making such an appeal, and had to go a weekend without food.Running Makana FAThe Makana Football Association was founded after authorities relented in 1967. A disciplinary committee, as well as a referees’ union, were formed as part of the association.Up to 27 teams competed in the league, which stuck to stringent Fifa guidelines. The international federation honoured its founders in 2007 by making Makana Association an honorary member.While Rivonia Treason Trialists including Nelson Mandela, Walter Sisulu and Ahmed Kathrada were barred from participating and even watching matches, then-youngsters like Jacob Zuma, Tokyo Sexwale and the four De Montfort University honoraries took to the field as players.Today Zuma is president of South Africa and Sexwale the minister of human settlements.“We were also young at that time, full of energy, and we needed to expend that energy,” Sitoto said in an interview published on the Fifa website in 2007.“We wanted to get closer to one another because we were in different areas of the prison, and one way to do this was through sport.”The political activists treated the football association “not just as an escape from the relentless and exhaustive regime on the island, but as a practice at running a government”, noted De Montfort University.Visiting Professor Charles Korr at the university’s International Centre for Sports History and Culture has documented in detail the story of the four unsung heroes. He co-authored the book More Than Just a Game and co-produced a film of the same title. “(Football) helped them to retain their sense of dignity and to continue the fight to create a free, non-racist South Africa,” Korr said in a statement.“Winning the right to play football and successfully maintaining a league gave them one link to the pleasures of ordinary life before imprisonment,” he added. The road to the 2010 Fifa World Cup, which was successfully held in South Africa, actually started on Robben Island, local organising committee boss Danny Jordaan commented recently.last_img read more

BARTOLOME (GALAPAGOS) — Geocache of the Week

first_imgThe Galapagos Islands are well-known for their expansive population of species. About 80% of the land birds, 97% of the reptiles and land mammals, and more than 30% of the plants are endemic, which means “belonging exclusively or confined to a particular place”.Seldom in nature can you be approached by a wild animal. Bartolome (Galapagos) GC1KGT8 can bring us up close and personal to nature. The island is also a geologist’s playground—so it makes perfect sense that a truly wonderful EarthCache is here.The little island, Bartolome, is only 1.2 square kilometers (297 acres). Rocky pillars of basalt called “tuff cones” jut out from the surface of the island. These pillars are remnants of hardened fallout of a volcanic eruption. One of the great rewards of GC1KGT8 is the stunning postcard view of the prominent Pinnacle Rock, the largest tuff cone on the island.On the path to the beach, just offshore, you will find a large volcanic crater that is encapsulating. If you brought your snorkeler you are in for a treat! According to the cache page the northern beach is open for swimming and the beaches of Bartolome Island are filled with fluorescent fish, playful sea lions, and even whale sharks! EarthCacheGC1KGT8by boiler Share with your Friends:More SharePrint RelatedAn Easter (Island) Geocache – Rano Kau – Rapa Nui (GC22ZGB) – Geocache of the WeekMarch 27, 2013In “Community”7 Continents, 7 EarthCachesOctober 3, 2017In “Community”GeoTour Azores (GT6F)November 13, 2018In “GeoTours” Difficulty:1Terrain:2.5center_img The trail ends with a rock path and a long wooden stairway (~360 steps) brings you through the lunar landscape with almost no visibility up to summit hill and the viewpoint of Pinnacle Rock.If you are EarthCaching on Bartolome Island here are some notable vocabulary terms to take with you as per the cache page:1.) Lava tubes: Formed by flowing rivers of lava whose outer layer cools and solidifies quicker than the core (creating a skin). The liquid lava continues to flow through the middle, hollowing out an area creating a tube like structure.2.) Spatter cones: These cones are either a deep red, gleaming black or intense green. The cones are formed when the pressure of gases below the magma in an active lava flow push upward. The gases escape carrying big pieces of lava into the air. The outside of the lava cools down and turns black, and when it hits the ground, the lava ball bursts open releasing the hot magma inside.3.) Lava bombs: The outcome of a spatter cone. The outside surface of lava bombs are smooth, but the inside of the lava bomb bursts open with broken fragments, creating A’a lava. The broken lava is very runny. However, once the gases all escape, the lava will start to slow, creating pahoehoe lava.Here’s what our fellow cachers had to say about their experience:One of the most beautiful landscapes in the Galapagos so far! What an awesome trip Elm77 and I are having. The climb was a breeze for me and the view spectacular. Our guide knew a lot about the geology of the area so I learned a lot! Answers and picture will be sent as soon as I get home. Thanks for the lesson! –PomwoofLast year on my 40th birthday I made myself the present of a Galapagos dive trip.  And by doing so a dream came true. As a group of 16 divers from Switzerland we were able to charter the “Galapagos Aggressor” for our trip.On the second day of diving after two dives at Punta Carrion we set foot on Bartolomé Island for a land tour.  Of course I had already hoped at home that I would get the opportunity to visit one of the few caches around the Galapagos Archipelago.I enjoyed the hiking a lot, admired the view from the top and even had the chance to see sea lions, penguins, Darwin’s finches, a lizard and a blue-footed booby – part of the animals on land, part while riding the zodiac. –HaiopaiaThank you boiler for cooking up this hot EarthCache. Is that name a coincidence? I think not. Check out the beautiful photography from geocachers who have visited Bartolome Island and in the gallery below!             A  OLYMPUS DIGITAL CAMERA        Location:GalapagosS 00° 17.046 W 090° 33.048 The trail continues to lead you across a sandy isthmus to another beach at the southern end of the island. Swimming here is not welcome, and not as friendly. White tip sharks have been known to enter the waters and the cache owner Boiler warns of hostile ghost crabs in that area.last_img read more

Here’s What UStream’s Big iPhone App Update Will Include

first_imgWhy IoT Apps are Eating Device Interfaces The Rise and Rise of Mobile Payment Technology marshall kirkpatrick Role of Mobile App Analytics In-App Engagement What it Takes to Build a Highly Secure FinTech …center_img Live video viewing and broadcasting service UStream appears set to unveil a dramatic update to its iPhone app, the first update the app has seen in many months. UStream, a deep-pocketed gamble on the future, really needs a better iPhone app. This new version looks a lot better; these changes are long overdue. This app looks like something I want to use to view and create live mobile video.The company put up a post on its blog this evening with screenshots and details of the launch, but pulled the post, probably because the app isn’t live yet in the iTunes store. None the less, you can see the screenshots and highlights of the new version below.For those of you with two phones in your pocket comparing apps across platforms, it appears that most if not all of these updates have been available in the UStream Android app for the past few months. Competition doesn’t sit still, either. Rumors emerged earlier this month that Apple’s MobileMe product might be remade as a Foursquare/UStream mashup of sorts. We’ll see. Given that the company has raised a fair sum of money and that live mobile video is supposed to be all the rage someday, ought UStream not have a little more than this up its sleeve for its first iPhone app update in months? Either way, I’m looking forward to it.Highlights from the pending UStream release include:Broadcasting and viewing will now finally be possible through the same single app. UStream previously offered live mobile broadcasting through one app (last updated in November) and viewing other peoples’ live shows through another (last updated in July). Now there will be just one app for both. It’s much more attractive than either the broadcaster or the viewer, too.Featured content and sorting by categories. It’s hard to find good content on the UStream app, but the screenshot of featured live and recorded shows indicates the company is set to overcome this major hurdle in making the app worth using. In testing the old app just minutes ago, I was able to view live chatter between astronauts climbing around on the outside of the space station – on my phone! I was also able to see a well-endowed woman disrobe in front of a radio microphone while voices from off-camera shouted in Spanish about Wikipedia. Both live broadcasts truly were marvels of the modern age. Featured content will be a big improvement though, presuming there’s enough good things to feature.Users can now log-in with Facebook or Twitter, in addition to their UStream accounts. That’s a very smart change.Broadcasters will now be able to run polls from the app.Subscribers can sign up for push notifications for channels or events of interest being broadcast live.Can changes like these help UStream move beyond the topless astronaut crowd? Time will tell, but they sure look like big improvements to me. I like the idea of being able to view and broadcast live video from my phone. I’ll test the app and report back on performance once it’s live. Related Posts Tags:#mobile#web last_img read more

Rumble Strips and Feedback

first_img Essential Reading! Get my first book: The Only Sale Guide You’ll Ever Need “The USA Today bestseller by the star sales speaker and author of The Sales Blog that reveals how all salespeople can attain huge sales success through strategies backed by extensive research and experience.” Buy Now You know how you are sometimes driving down the road and you run a little bit off course? Rumble strips are those lines carved into the side of the road that create a loud noise and vibration. They are they to provide you with the feedback that you’re slightly off the road. Without rumble strips you might run off the road–or far enough onto the shoulder–that something bad happens. Rumble strips also tell you to slow down on freeway off-ramps, that you are going too fast to safely exit.Rumble strips are annoying. They’re designed to get your attention and provide feedback when feedback is necessary.Your Rumble Strips Are QuietAll of the results that you’re generating in sales and business also come with feedback. But most of the feedback doesn’t easily command your attention.When things are working the feedback is positive. You’re winning opportunities. You’re improving. Things are moving forward for you fast. No alarm bells are sounding. But you’re also provided feedback when things aren’t working quite so well. Even this feedback may not garner your attention.When your dream clients aren’t responding to your attempts to capture their time and attention it’s feedback that what you’re doing isn’t creating value for them. Their silence is feedback. That silence should jar you to action just like rumble strips.When your pipeline is shallow, when you don’t have enough opportunities, it’s feedback that your prospecting efforts aren’t working. Maybe it’s feedback that what you’re doing isn’t working, but maybe it’s feedback that you just aren’t doing enough. Either way, it’s feedback that you need to make some adjustment to what you’re doing, that you’re off course.When your inside team struggles to execute on what you sold it might be feedback that you’re giving them a poor handoff. Or it might also mean that you’re selling something that your team can’t easily deliver. Maybe your team just needs your help selling inside to acquire the resources they need to execute. More feedback, if you are keen enough to observe the noise your team makes.The results that you’re producing, good or bad, come with feedback. That uncomfortable feeling you get when things aren’t working is like driving over rumble strips. It’s supposed to warn you, to jar you loose from your comfortable state and make you aware that you need to change. It means you’re slightly (or seriously) off course and need to make corrections.Pay attention to the rumble strips. Pay attention to the feedback (and remember sometimes the feedback is silence).QuestionsWhat kind of feedback are you receiving?How do you know when you’re slightly off course?What kind of warnings do yo get that you are going to fast for your client, that your speed is jeopardizing an opportunity?Like driving, are you normally way off course, or does a slight correction make an enormous difference?last_img read more

Cousins to square off in Bikaner

first_imgTwo cousins are fighting it out as the candidates of rivals Congress and BJP on Rajasthan’s Bikaner Lok Sabha seat. Both the candidates have served the government as civil servants in the past, while the elder one is at present a Union Minister. The younger cousin has made a debut in politics after taking voluntary retirement from the Indian Police Service.Union Minister of State for Water Resources Arjun Ram Meghwal is contesting as the BJP candidate for the third time, while his cousin Madan Gopal Meghwal is a Congress candidate for the first time. Mr. Arjun Ram had entered politics in 2009 after resigning from the Indian Administrative Service and won the Bikaner Lok Sabha seat.Mr. Madan Gopal, who left IPS before the 2018 Assembly election and unsuccessfully tried for a Congress ticket from Bikaner’s Khajuwala seat, has received support from an unexpected quarter in the Lok Sabha poll. Veteran Rajput leader of the BJP, Devi Singh Bhati, who has quit the party in protest against the ticket being given to Mr. Arjun Ram, has extended his support to the Congress.BJP State president Madan Lal Saini accepted Mr. Bhati’s resignation on Friday. Mr. Bhati, a seven-time MLA from Kolayat, had alleged that Mr. Arjun Ram’s political activities had harmed the party and led to its defeat in the Assembly election.While Mr. Madan Gopal affirms that he respects Mr. Arjun Ram as his elder cousin despite differences in their political ideologies, Mr. Bhati’s supporters have disrupted the latter’s public meetings several times during the ongoing election campaign. On Thursday, Mr. Bhati’s supporters showed black flags and raised slogans at a meeting, after which they reportedly clashed with the BJP workers in Bikaner city.The Bikaner seat has been a stronghold of the BJP since 2004, when film actor Dharmendra won it on the party’s ticket. It was reserved for the Scheduled Castes in the 2009 delimitation exercise, after which the caste equations changed and the Dalits and the OBCs shifted towards the Congress.The upper castes, which are in a sizeable number in the constituency, are reportedly unhappy with Mr. Arjun Ram following his support to the April 2, 2018, agitation of Dalits against the Supreme Court’s ruling on the SC/ST (Prevention of Atrocities) Act. Mr. Arjun Ram was accused of inciting violence in Bikaner district during the protest.last_img read more