It has been nearly four days now since international media outlets announced that at least two Ebola trial vaccines were expected to arrive in the country on Friday, January 23. It seems no one higher up in government or those managing the nation’s Ebola crisis knows anything about the ChAd-3 and Vesicular Stomatitis Virus (VSV) vaccines, whether they have been shipped to, or are now in Liberia, by GlaxoSmithKline, a British national pharmaceutical, biologics vaccines and consumer healthcare company.The company said the trial drugs have already been “shipped” to Liberia. It developed the vaccines in collaboration with National Institute of Allergy and Infectious Diseases (NIAID), which is part of the US National Institutes of Health (NIH).The NIAID/GSK Ebola vaccine is based on a type of chimpanzee cold virus, called chimp adenovirus type 3 (ChAd-3). The manufacturers said the adenovirus is used as a carrier, or vector, to deliver segments of genetic material derived from two Ebola virus species: Zaire Ebola and Sudan Ebola. Hence, this vaccine is referred to as a bivalent vaccine. “The Zaire species of the virus is responsible for the current Ebola outbreak in West Africa.”“The vaccine candidate delivers one part of Ebola’s genetic material to human cells, but the adenovirus vector does not replicate. Rather, the Ebola gene that it carries allows the cells of the vaccine recipient to express a single Ebola protein, and that protein prompts an immune response in the individual.It is important to know that the Ebola genetic material contained in the investigational vaccine cannot cause a vaccinated individual to become infected with Ebola.”The Daily Observer contacted several highly placed officials over the weekend and Sunday, who confirmed that they have heard about the vaccines but could not say whether they were now on the ground in Liberia or otherwise. Most promised to get back sometime this Monday afternoon with answers after finding out the status of the vaccines.One eminent Liberian, who asked not to be named, described the “I don’t know” attitude of these officials, who should know everything about the running of the state especially the vaccines that have been widely publicized, as “lackadaisical.” This person added: “These are the kind of people we have running the state of affairs and playing with the lives of ordinary Liberians.” However, Mr. David Sumo, Managing Director, Liberia Medicines and Health Products Regulatory Authority (LMHRA), confirmed that he had received an application from the United States Government’s National Institutes of Health (NIH), asking his entity to grant approval for the trial of both vaccines to be carried out in Liberia.Mr. Sumo’s LMHRA is tasked with the statutory mandate of ensuring that every medical supply that comes to the country is safe, effective and of good quality before it reaches the Liberian public. It is also tasked with protecting Liberians from the harmful effects of substandard and counterfeit medicines and health products.“We are aware because the sponsors [NIH] did apply in accordance with our guidelines,” Mr. Sumo told our Health Correspondent Saturday.He said two separate ethical committees — one at his entity and another at the Ministry of Health — have been meeting separately, looking into documents sent in by the sponsors.“For us, we are going to respond officially to them by Monday (today) latest. From our side, there are still some outstanding issues that we have noticed with their document which need to be addressed,” he stated. He, however, clarified that some of the issues won’t stand in the way of the trial process.Mr. Sumo disclosed that this is going to be the “phase 2 trial” of the vaccines, which, according to him, have already undergone phase 1 trial in a few countries, including Mali, USA and Switzerland.“With the information obtained from the first trial, we can now go into the phase 2 trial if our outstanding issues are resolved.”He stated that at least 600 participants, who are going to be mostly health workers, have been earmarked for phase 2. The third phase, will target at least 9,000 persons at an unknown date.“All the participants are going to agree voluntarily to undergo the trial. They will be told all the side effects and that the drugs are trial. They would have to agree and sign before being allowed to undergo the trial,” he emphasized.Mr. Sumo, however, clarified that every participant will be followed and monitored for at least a year in order to make sure that they remain healthy and don’t develop any sickness as a result of the trial.He stated that the vaccines will be administered to healthy Liberians, who will be thoroughly screened.He told our health correspondent that once participants come out of the trial well, it means that they have now been vaccinated against the Ebola virus disease and can’t contract the deadly virus even if they came in contact with an infected person or object.He disclosed that the vaccines will be stored below minus 30 degrees Celsius at the US Embassy. This is probably because there is no public facility equipped with such a cooling system.A US Embassy official, who asked anonymity, didn’t confirm or deny this report, but said, “As far as we have been told, the vaccines have not yet landed in Liberia.”GlaxoSmithKline, Vaccine ManufacturersAuthorities of GlaxoSmithKline have stressed that the vaccine is still in development and the World Health Organization (WHO), and other regulators, would have to be satisfied the vaccine is both safe and effective before any mass immunization campaigns could be considered.According to the BBC, field trials of other promising vaccines – for example one involving the company Merck – are planned in Guinea, Liberia and Sierra Leone in the months to come.These three countries are the hardest hit nations.However, experts say with the number of Ebola cases falling opportunities to test vaccines and drugs could be limited.Share this:Click to share on Twitter (Opens in new window)Click to share on Facebook (Opens in new window)
The photo was pulled from Pinterest, where Gagnier says it’s normally easy to find an image source. However, in this case, Lonny gave credit to the network itself. Gagnier says she would adjust the credit if anyone let her know who took the picture. “Our followers seem to respond well to dramatic lifestyle and landscape images, and this photo with all of the flowers in bloom really stuck out to me,” says Briana Gagnier, photo editor at Lonny, which launched in 2009 and is published by Livingly Media. “I think this post was successful because it’s eye-catching and shareable. If you see something that makes you say, ‘wow,’ you’re going to want to share that with someone,” Gagnier says. “And high shareability leads to more engagement and impressions.” Number of likes: 6,903 // Number of comments: 96 // Impressions: 80,800 Perhaps that’s why this post of the flowery Churchill Arms Pub and Restaurant in London saw more than double the brand’s the normal engagement, making it the most-liked Instagram post by Lonny, yet. Magazine: Lonny // Instagram: @lonnymag // Social Editor: Briana Gagnier // Photo Credit: Unknown/Pinterest Pro Tip: Source from Pinterest and other social networks to add some diversity to your magazine’s aesthetic — but always give credit where credit is due. Most of Lonny’s Instagram posts are of fresh and contemporary interior designs, giving followers a taste of how rugs and pillows can come together to transform a room into a piece of art. But every once in a while, the California-based digital design magazine — “Your go-to resource for accessible design inspiration” — posts something more inspirational than accessible.
A nine-month-old dogecoin, a cryptocurrency has been soaring recently and touched its highest value since May, on Saturday. This has lead to the speculation that investors pump money into the cryptocurrencies to artificially inflate its price and later sell it off for a profit. Another factor that may have led to the increase in the price of dogecoin is switching the virtual currency to auxiliary proof of work (AUXPoW) or merge mining. This will allow investors to transact currency by providing an additional security to the decentralised network, according to coindesk.The sudden boost has driven market cap of dogecoin to $91 million eventually and around $40 million in one week, reported CoinDesk.However, experts opine that this boost is short-lived.”What’s happening now is a lot of investors are buying in because they see dogecoin as an attractive investment,” said a member of sub-reddit registered in the name of such_investor.US Approves Bitcoin Swap:A derivatives exchange has become the first to receive approval from US Federal Regulator on Friday as TeraExchange got approved from the Commodities Future Trading platform.This would allow investors to switch over to digital currency under the approval of US Federal reserve.Christian Martin, Tera Exchange’s CEO told Wall Street Journal: “A robust price index also helps the growing bitcoin trading community to accurately mark-to-market positions while establishing trust and stability in this growing global marketplace.”
Bobby HajjajFive mayoral contenders will contest the by-polls to Dhaka North City Corporation (DNCC) after Jatiya Ganotantrik Andolan candidate Bobby Hajjaj quit the electoral race.Hajjaj withdrew his candidature within the stipulated time that expired on Saturday, said returning officer Abul Kashem.The remaining candidates are – Awami League’s Atiqul Islam, Jatiya Party’s Shafin Ahmed, NPP’s Anisur Rahman Dewan, PDP’s Shahin Khan and independent contender Mohammad Abdur Rahim.The by-elections to the vacant mayoral post will be held on 28 February.Besides, by-polls to councillor posts of 36 new wards – 18 in DNCC and as many in Dhaka South City Corporation – will be held on the same day.
Under a reorg at AT&T’s WarnerMedia, Tony Goncalves, CEO of Otter Media, will now lead the development of the forthcoming WarnerMedia direct-to-consumer service.In addition, Andy Forssell, most recently COO of Otter Media and former CEO of Hulu, will move into the role of EVP and GM of the new, as-yet-unnamed streaming service, reporting to Goncalves.With the changes, Brad Bentley is exiting WarnerMedia Entertainment group as EVP and GM for direct-to-consumer development after six months in the role.The executive reshuffling comes as WarnerMedia has moved Otter Media under the oversight of the WarnerMedia Entertainment group, headed by Bob Greenblatt, chairman of WarnerMedia Entertainment and Direct-To-Consumer. Goncalves, who continues to oversee Otter’s existing brands and services, now reports to Greenblatt; previously he reported up to WarnerMedia CEO John Stankey, a longtime AT&T exec who took over the reins at the former Time Warner. How an Economic Downturn Could Ravage Hollywood Related Kevin Reilly, president of TBS, TNT and TruTV and chief content officer for the direct-to-consumer service, will remain in that position, reporting to Greenblatt.Last November, WarnerMedia CEO John Stankey had appointed Bentley, previously a longtime DirecTV exec, into the GM role overseeing all aspects of the company’s direct-to-consumer streaming service. The exit of Bentley, who played a similar role in the launch of DirecTV Now, suggests the WarnerMedia subscription VOD product may have been missing deadlines or other targets.WarrnerMedia’s direct-to-consumer SVOD service will pull together content from HBO, Warner Bros. and Turner cable networks as well as original programming. It’s slated to debut in the U.S. in a beta form in the fourth quarter of 2019, with a full launch in Q1 2020.“I’m confident that with Tony and Andy leading our product and operations, Kevin and HBO’s Casey Bloys guiding our content strategy, and with Bob at the helm, we have a formidable team creating a curated streaming service with a winning combination of content and features,” Stankey said in a statement.About Bentley, Stankey added, “I also want to thank Brad for his leadership in bringing the project to this point in record time.”AT&T has set big expectations for the new WarnerMedia SVOD service, which will vie against not only Netflix, Hulu and Amazon Prime Video but also Disney Plus, slated for a Nov. 12 launch. AT&T CEO Randall Stephenson, at an investment conference this month, said it will “become a significant driver of our growth over the next few years as we stand this product up… We think this is in the tens of millions of subscribers that we will have on this.”Otter Media’s business comprises Fullscreen, focused on branded content and influencer marketing; anime streaming service Crunchyroll; Rooster Teeth, focused on sci-fi, gamer and anime-style content; and VRV, a subscription VOD aggregation service.Greenblatt, in a statement, said, “The thriving Otter Media businesses are important to this company and I’m happy to welcome Tony and Andy to our direct-to-consumer team. This group’s expertise will be invaluable to our new streaming service as we aim to bring content from the best storytellers in the world to an audience that expects the highest quality digital experience.” Popular on Variety Goncalves joined Otter Media as CEO last year, when it was still a joint venture between AT&T and Chernin Group. (AT&T announced the deal to buy out Chernin Group’s stake in the venture in August 2018.) Previously, Goncalves was CEO of AT&T’s Digital Brands and head of strategy and business development. He came to AT&T with the telco’s acquisition of DirecTV, where he had held various management roles, most recently as SVP of the digital entertainment products group.Forssell came to Otter from Fullscreen, where he had served as COO since 2015. He previously served as CEO of social-video startup ShowYou (acquired by Vevo), after stepping into the CEO role at Hulu with the exit of founding CEO Jason Kilar in 2013. Forssell had been at Hulu since 2007, shortly after its formation.WarnerMedia had already taken several steps to restructure Otter Media. The changes included shifting Machinima from Warner Bros.’s aegis to Otter Media — which then effectively shut down Machinima and folded some remaining staff into groups at Fullscreen and Rooster Teeth. Otter Media also folded the Fullscreen Live in-person tour group and the Fullscreen Direct fan-engagement service.In addition to its operating business units, Otter Media’s portfolio includes a majority stake in digital-first studio Gunpowder & Sky and minority stakes in Reese Witherspoon’s Hello Sunshine content company for women and Mars Reel high school athletes. Style Icon Jenna Lyons on Launching New Unscripted Series on Turner TV ×Actors Reveal Their Favorite Disney PrincessesSeveral actors, like Daisy Ridley, Awkwafina, Jeff Goldblum and Gina Rodriguez, reveal their favorite Disney princesses. Rapunzel, Mulan, Ariel,Tiana, Sleeping Beauty and Jasmine all got some love from the Disney stars.More VideosVolume 0%Press shift question mark to access a list of keyboard shortcutsKeyboard Shortcutsplay/pauseincrease volumedecrease volumeseek forwardsseek backwardstoggle captionstoggle fullscreenmute/unmuteseek to %SPACE↑↓→←cfm0-9Next UpJennifer Lopez Shares How She Became a Mogul04:350.5x1x1.25×1.5x2xLive00:0002:1502:15
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Click for Sound Video Loading Video Unavailable The video will start in 1Cancel Play now How to download The Sentinel’s new FREE app Watch Next Share this video Video will play in Click to playTap to play Watch again We pay for stories! Send your videos to firstname.lastname@example.orgWelcome to The Sentinel’s breaking news service bringing you all the latest updates from Stoke-on-Trent and North Staffordshire on Thursday April 5 Our team of reporters will be updating this live service with all the latest on the weather, traffic and travel as well as news, sport and entertainment through the day. We’ll be bringing you the very latest updates in our live news feed below. For the latest news and breaking news visit www.thesentinel.co.uk . Get all the big headlines, pictures, analysis, opinion and video on the stories that matter to you. Follow us on Twitter @ SentinelStaffs – the official Sentinel account – real news in real time. We’re also on www.facebook.com/sentinelstaffs – your must-see news, features, videos and pictures throughout Stoke-on-Trent, North Staffordshire & South Cheshire. Key EventsAir ambulance called to M6 crash17:1117:44More issues on the M6Slow traffic and one lane blocked due to broken down vehicle on M6 Southbound between J19 A556 (Knutsford) and J18 A54 (Middlewich / Holmes Chapel). In the roadworks area.Lane one (of three) is blocked less than half a mile before J18. 17:43Person hit by train in BirminghamServices being diverted via Solihull on CrossCountry and trains not stopping at Coventry, and at Birmingham International due to person hit by a train at Marston Green. Tickets being accepted on local bus routes. 17:11KEY EVENTAir ambulance called to M6 crashThe scene of the M6 accident (Image: Highways England)The air ambulance was called to the M6 after a crash involving two lorries forced two lanes to close.Emergency services were called to the scene on the northbound carriageway between junctions 13 and 14, for Stafford at around 3.24pm.One of the drivers was trapped in his vehicle, but was freed by Staffordshire Fire and Rescue Service crews and taken to hospital via land ambulance.Read more here.15:44Long delays on the M6Queueing traffic and long delays due to earlier accident on M6 Northbound between Stafford Services and J15 A500 (Stoke-On-Trent), congestion on M6 to J13 A449 (Stafford South). Travel time is around 50 minutes. All lanes have been re-opened.Lane one (of three) was closed. All restrictions were lifted at around 15:25. Stafford Services is located between J14 and J15. 13:43Road blocked after fireA5005 Commerce Street Southbound is partially blocked due to building fire from A50 Market Street to Commerce Street.The one way system here is partially blocked to assist.13:15Check out this new £13.5 million care home – which even has its own pub!Residents preparing to move into a £13.5 million care village on the site of a former nightclub will have their own tea room, hairdressers – and pub.And the Belong facility in Newcastle – which will open its doors next week – will also play host to an exercise studio and therapy room alongside a gallery to celebrate the site’s past.Check out everything on offer there in our report. Staff prepare to welcome residents to the new care village12:56Man, 34, dies after being hit by train on way home from gigA 34-year-old man has died after being hit by a train after returning home from a gig.Drummer Asa Simpson, from Newcastle, was tragically killed early on Saturday morning (March 31).He was well-known across the area as a member of Stoke-on-Trent four-piece Exowaves.The band had played a gig at De Bees in Winsford the night before his death shortly after 8am.Asa Simpson was a drummer with Exowaves (Image: Twitter)12:16HUGE rise in scarlet fever in Stoke-on-Trent and StaffordshireAlmost 200 cases of scarlet fever have been reported in Stoke-on-Trent and Staffordshire in the first three months of the year – TWICE as many as last year.New figures from Public Health England show there have been 171 suspected cases of the illness between January 1 and April 1.Read our full report here. 11:41Broken down vehicle on M6 SouthboundOne lane of the M6 is closed due to a broken down vehicle Southbound between J13 A449 (Stafford South) and J12 A5 (Gailey). Traffic is coping well.Lane one (of four) is closed.11:41Heavy traffic going into city centreThere is heavy traffic on Bucknall Road inbound from A52 Leek Road (Lime Kiln Traffic Lights) to Hanley Town centre at the moment.11:21’I thought he was going to kill me’ – Stoke-on-Trent mum, 36, reveals how she was regularly attacked by nine-year-old sonA Stoke-on-Trent mum has told how she feared she could die at the hands of her nine-year-old son because of his violent and uncontrollable rages.Single mum-of-four Debbie appeared on ITV’s This Morning under the headline ‘I thought my son was going to kill me’ yesterday.Mum Debbie divided viewers on This Morning10:57Big changes at The Marzipan Pig!The owners of a much-loved city centre coffee shop and lifestyle store are preparing to close the business – to focus on their mouth-watering cakes.And customers are being invited to join Gav and Heather Tilstone for a special ‘cake smash’ to mark their last day at The Marzipan Pig later this month.Read more about it here.Heather and Gav Tilstone with some of the made-to-order cakes10:30Top story on The Sentinel website todayToday’s top story online, based on page views, is ‘Drug addicts and prostitutes’ caught on CCTV breaking into coin-operated toilets – weeks after they opened.The toilets were only recently opened to the public08:40Need some ideas to keep the kids entertained during this Easter break?Look no further than our list of 10 days out you can do from Stoke-on-Trent with just over £5 of petrol. You can get so much further than you think! We picked out some of our favourite spots that seem far away, but are actually surprisingly cheap and easy to get to. Days out with just a fiver of petrol – how far can you get?08:23Wheelie bin set on fire in Baddeley GreenHanley firefighters spent the early hours of the morning tackling a bin fire in Baddeley Green. The crew was called at 2.38am to a wheelie bin fire on Baddeley Hall Road. 08:10Emergency services attended two-car collision in Burslem where vehicle ended up on roofA car ended up on its roof after a collision on Moorland Road in Burslem, last night.Firefighters from Hanley and Sandyford attended the incident at 11.42pm. The Sandyford crew dealt with the aftermath of the two-car crash, but all people were out of the cars by the time they got there.07:46Morning everyoneThanks for being with us on April 5, 2018. We’ll be bringing you the latest news, traffic and travel updates, and more throughout the day.